Rachel C. Vreeman, MD, MS

Associate Professor of Pediatrics, IU School of Medicine
Co-Director (North America), AMPATH Research Network
Joe and Sarah Ellen Mamlin Scholar of Global Health Research
Director of Research, IU Center for Global Health Research
Faculty Investigator, Center for Health Policy and Professionalism Research, IUSM

   Dr. Vreeman is an Assistant Professor of Pediatrics at the Indiana University School of Medicine, an Affiliated Scientist at the Regenstrief Institute for Health Care, and a member of the Riley Children’s Health Services Research Program.  She is also Director of Research at the Indiana University Center for Global Health, Indiana University School of Medicine and the Joe and Sarah Ellen Mamlin Scholar of Global Health Research, Indiana University School of Medicine.  In addition, she is Co-Director of Pediatric Research for the Academic Model for the Prevention and Treatment of HIV/AIDS (AMPATH), an academic collaboration that provides comprehensive HIV treatment for over 70,000 patients in Kenya.


   Dr. Vreeman’s research addresses two key long-term clinical challenges for children living with HIV: enhanced pediatric adherence to antiretroviral therapy (ART) and disclosure of HIV status in AMPATH pediatric HIV/AIDS clinics in Kenya.  In addition, she has provided guidance to pediatric HIV care issues for AMPATH, including developing and implementing pediatric clinical decision support, improving results reporting for HIV-exposed children, and facilitating monthly adolescent support groups.


   Dr. Vreeman serves as Chair for the Global Pediatric Working Group, International Epidemiologic Databases  for the Evaluation of AIDS, at the National Institutes of Health and on the Adolescent Transition Technical Committee for the International AIDS Society.  She is the recipient of the Watanabe Translational Research Scholar Award from Indiana CTSI.

Dr. Vreeman is board certified in Pediatrics. 


Indiana University Health Profile



  Health Services Research
  Global Health



Physician Groups:  Riley Physicians
 IU Health Physicians
Hospital Privileges:  IU Health Methodist/IU Health University
 Riley Hospital for Children at IU Health



School of Medicine   Michigan State University College of Human Medicine   
Fellowship   Children's Health Services Research
Internship, Residency and Chief Residency   Indiana University School of Medicine  
Master of Science in Clinical Research     Indiana University School of Medicine  

Active Projects

I. NIH-NIMH (2012-2016)

"Patient-Centered Disclosure Intervention for HIV-Infected Children."

The purpose of this study is to assess the effect of a patient-centered intervention guiding disclosure to HIV-infected Kenyan children, using a cluster randomized trial comparing the intervention to routine care. This work is being performed within a long-standing US-Kenya partnership, the Academic Model Providing Access to Healthcare (AMPATH), which currently cares for almost 120,000 adult and pediatric HIV-infected patients in 25 clinics in Kenya.


II. NIH-NIAID U01 (2011-2017)

“International Epidemiologic Databases for the Evaluation of AIDS – IeDEA” (Wools-Kaloustian, PI)

The East African IeDEA Regional Data & Coordinating Center Indiana University School of Medicine serves as the East African IeDEA Regional Data & Coordinating Center in the United States. It provides overall coordination for the East African Consortium including data management and statistical analysis support. In addition the site provides mentoring and practical support to the data managers and biostatisticians at East Africa IeDEA sites. It is the long-range goal of this consortium to provide answers to the questions that clinicians, programs, and ministries of health consider fundamental to the evolution and sustainability of their long term HIV care and treatment strategies. Role: Co-Investigator

III. Supplement to NIH-NIAID U01 (2014-2015)

“IeDEA Comprehensive Adherence Measure for Pediatrics (ICAMP)” (PI)

Supplement to validate adherence measure in East Africa, South Africa, and Thailand.

Selected Publications                                |                            Go To PubMed List >>


1. Vreeman RC, Nyandiko WM, Liu H, Tu W, Scanlon ML, Slaven JE, Ayaya SO, Inui TS. Comprehensive Evaluation of Caregiver-Reported Antiretroviral Therapy Adherence for HIV-Infected Children. AIDS and Behavior. 2015 Apr;19(4):626-34.

2. Vreeman RC, Nyandiko WM, Liu H, Tu W, Scanlon ML, Slaven JE, Ayaya SO, Inui TS. Measuring adherence to antiretroviral therapy in children and adolescents in western Kenya. Journal of the International AIDS Society. 2014 Nov 25;17:19227. eCollection 2014.

3. McHenry MS, Apondi E, Vreeman RC. The importance of nutritional care in HIV-infected children in resource-limited settings. Expert Review of Anti-Infective Therapy. 2014 Dec;12(12):1423-6.

 4. Vreeman RC, Nyandiko WM, Liechty EA, Busakhala N, Bartelink IH, Savic RM, Scanlon ML, Ayaya SO, Blaschke TF. Impact of adherence and anthropometric characteristics on nevirapine pharmacokinetics and exposure among HIV-infected Kenyan children. Journal of Acquired Immune Deficiency Syndromes. 2014 Nov 1;67(3):277-86.

5. McHenry MS, Dixit A, Vreeman RC. A Systematic Review of Nutritional Supplementation in HIV-Infected Children in Resource-Limited Settings. Journal of the International Association of Providers of AIDS Care. 2014 Jun 18. pii: 2325957414539044. [Epub]

6. Mostert S, Njuguna F, Langat SC, Slot AJ, Skiles J, Sitaresmi MN, van de Ven PM, Musimbi J,Vreeman RC, Kaspers GJ. Two overlooked contributors to abandonment of childhood cancer treatment in Kenya: parents' social network and experiences with hospital retention policies. Psycho-oncology. 2014 Jun;23(6):700-7.

7. Njuguna F, Mostert S, Slot A, Langat S, Skiles J, Sitaresmi MN, van de Ven PM, Musimbi J, Muliro H, Vreeman RC, Kaspers GJ. Abandonment of childhood cancer treatment in Western Kenya. Archives of Diseases in Childhood. 2014 Jul;99(7):609-14.

8. Atwoli L, Ayuku D, Hogan J, Koech J, Vreeman RC, Ayaya S, Braitstein P. Impact of domestic care environment on trauma and posttraumatic stress disorder among orphans in western Kenya. PLoS One. 2014 Mar 13;9(3):e89937. eCollection 2014.

9. Vreeman RC, Scanlon ML, Mwangi A, Turissini M, Ayaya SO, Tenge C, Nyandiko WM. A cross-sectional study of disclosure of HIV status to children and adolescents in western Kenya. PLoS One. 2014 Jan 27;9(1):e86616. eCollection 2014.

10. Mostert S, Njuguna F, van de Ven PM, Olbara G, Kemps LJ, Musimbi J, Strother RM, Aluoch LM, Skiles J, Buziba NG, Sitaresmi MN, Vreeman RC, Kaspers GJ. Influence of health-insurance access and hospital retention policies on childhood cancer treatment in Kenya. Pediatric Blood and Cancer.2014 May;61(5):913-8.

11. Odera EB, Kwobah C, Stone G, Some F, Vreeman RC. Sickle cell disease and HIV: a case highlighting management challenges for children in a resource-limited setting. Journal of the International Association of Providers of AIDS Care. 2014 Mar-Apr;13(2):113-6.

12. Huang KT, Owino C, Gramelspacher GP, Monahan PO, Tabbey R, Hagembe M, Strother RM, Njuguna F, Vreeman RC. Prevalence and correlates of pain and pain treatment in a western Kenya referral hospital. Journal of Palliative Medicine. 2013 Oct;16(10):1260-7.

13. Braitstein P, Ayaya S, Nyandiko WM, Kamanda A, Koech J, Gisore P, Atwoli L, Vreeman RC, Duefield C, Ayuku DO. Nutritional status of orphaned and separated children and adolescents living in community and institutional environments in uasin gishu county, kenya. PLoS One. 2013 Jul 26;8(7):e70054. [Epub]

14. Wachira J, Ndege S, Koech J, Vreeman RC, Ayuo P, Braitstein P. HIV testing uptake and prevalence among adolescents and adults in a large home-based HIV testing program in Western Kenya. Journal of Acquired Immune Deficiency Syndromes 2014 Feb 1;65(2):e58-66.

15. Vreeman RC, Gramelspacher AM, Gisore PO, Scanlon ML, Nyandiko WM.  Disclosure of HIV status to children in resource-limited settings: a systematic review. Journal of the International AIDS Society. 2013 May 27;16:18466. [Epub]


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