Thomas F. Imperiale, MD

Lawrence Lumeng Professor of Gastroenterology and Hepatology; Professor of Medicine, Indiana University School of Medicine
Research Scientist, Indiana University Center for Health Services and Outcomes Research
Research Scientist, William M. Tierney Center for Health Services Research, Regenstrief Institute, Inc.
Core Investigator, VA HSR&D Center for Health Information and Communication
Adjunct Professor, Richard M. Fairbanks School of Public Health at Indiana University-Purdue University of Indianapolis

     Dr. Imperiale is a Professor of Medicine in IU School of Medicine’s Division of Gastroenterology/Hepatology and staff gastroenterologist serving patients in four major Indiana hospitals. He holds research appointments in the IU Center for Health Services and Outcomes Research, the VA Center for Health Information and Communication, and Regenstrief Institute's William M. Tierney Center for Health Services Research.  His interests include tailoring screening for colorectal cancer based on individual patient risk, and using quantitative research methods in studying prevention of cirrhosis complications. Secondary research interests encompass prognosis and management of acute upper gastrointestinal hemorrhage, and assessment of new technologies to the application of digestive diseases.


   Recent recognition includes the Indiana University Trustee Teaching Award and Regenstrief Institute’s Outstanding Investigator Award.  Dr. Imperiale has mentored over thirty medical residents, faculty, and fellows. He is a named Fellow in the American Gastroenterological Association, a Member of the Association of American Physicians, and serves on the Editorial Boards of the journals, Annals of Internal Medicine and Evidence-Based Gastroenterology.  Dr. Imperiale’s publications include over 150 peer-reviewed articles.

Dr. Imperiale is board certified in Internal Medicine and a staff physician at the Richard L. Roudebush VA Medical Center in Indianapolis, Indiana.

Indiana University Health Profile



  Outcomes Research
  Colorectal Cancer Screening
  Upper Gastrointestinal Bleeding
  Technology Assessment for Digestive Diseases



Physician Group:  
     IU Health Physicians  
Hospital Privileges:  
     IU Health Methodist/IU Health University  
     Richard L. Roudebush VA Medical Center  



Residency      Case Western Reserve University
Internship      Case Western Reserve University
Fellowship      Yale University; Case Western Research University
School of Medicine      New York University

Active Projects

I. VA Cooperative Studies Program (2010-2015)

"Colonoscopy vs. Fecal Immunochemical Testing in Reducing Mortality from Colorectal Cancer (CONFIRM)" (PI) 

This study is to determine the true comparative effectiveness of colonoscopy relative to other proven non-invasive options.


II. Exact Sciences Corporation (2011-2015)

"Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advance Adenomatous Polyps and Cancer: DeeP-C Study." (PI)

Study is to determine the sensitivity and specificity of the Exact Colorectal Cancer (CRC) screening test for colorectal cancer, using colonoscopy as the reference method. The secondary objective is to compare the performance of the Exact CRC screening test to a commercially available FIT assay, both with respect to cancer and advanced adenoma.


III. Exact Sciences Corporation (2015-2019)

“”A Longitudinal Study of CologuardTM in an Average Risk Population Assessing a Three Year Test Interval” (PI)

The study objective is to collect longitudinal data on subjects prescribed Cologuard over the course of 3 years, to determine predictive value of the test, and to compare the observed versus expected reduction in colorectal cancer incidence.


Selected Publications                          |                          Go To PubMed List >>


1. Imperiale TF.  Genetic and environmental risk assessment and colorectal cancer screening. Annals of Internal Medicine. 2015 Apr 7;162(7):526-7.

2. Imler TD, Morea J, Kahi C, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A, Smalley W, Imperiale TF. Multi-center colonoscopy quality measurement utilizing natural language processing. American Journal of Gastroenterology. 2015 Apr;110(4):543-52.

3. Mundade R, Imperiale TF, Prabhu L, Loehrer PJ, Lu T.  Genetic pathways, prevention, and treatment of sporadic colorectal cancer. Oncoscience. 2014 Jun 30;1(6):400-6.

4Imperiale TF, Juluri R, Sherer EA, Glowinski EA, Johnson CS, Morelli MS A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps. Gastrointestinal Endoscopy. 2014 Sep;80(3):471-8.

5. Hou JK, Imler TD, Imperiale TF. Current and future applications of natural language processing in the field of digestive diseases. Clinical Gastroenterology and Hepatology. 2014 Aug;12(8):1257-61.

6. Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014 Apr 3;370(14):1287-97.

7. Kahi CJ, Myers LJ, Slaven JE, Haggstrom D, Pohl H, Robertson DJ, Imperiale TF. Lower endoscopy reduces colorectal cancer incidence in older individuals. Gastroenterology. 2014 Mar;146(3):718-725.e3.

8. Imler TD, Morea J, Imperiale TF.Clinical decision support with natural language processing facilitates determination of colonoscopy surveillance intervals. Clinical Gastroenterology and Hepatology. 2014 Jul;12(7):1130-6.

9. Dolan JG, Boohaker E, Allison J, Imperiale TF. Can Streamlined Multicriteria Decision Analysis Be Used to Implement Shared Decision Making for Colorectal Cancer Screening? Medical Decision Making. 2013 Dec 3;34(6):746-755.

10. Morelli MS, Glowinski EA, Juluri R, Johnson CS, Imperiale TF. Yield of the second surveillance colonoscopy based on the results of the index and first surveillance colonoscopies. Endoscopy. 2013 Oct;45(10):821-6.

11. Sherer EA, Ambedkar S, Perng S, Yih Y, Imperiale TF. A predictive model of longitudinal, patient-specific colonoscopy results. Computer Methods and Programs in Biomedicine. 2013 Dec;112(3):563-79.

12. Lin Y, Yu M, Wang S, Chappell R, Imperiale TF. Advanced colorectal neoplasia risk stratification by penalized logistic regression. Statistical Methods in Medical Research. 2013 Jul 30.

13. Imperiale TF. Sigmoidoscopy screening: understanding the trade-off between detection of advanced neoplasia and diagnostic efficiency. Journal of the National Cancer Institute. 2013 Jun 19;105(12):846-8.

14. Christy SM, Perkins SM, Tong Y, Krier C, Champion VL, Skinner CS, Springston JK, Imperiale TF, Rawl SM. Promoting colorectal cancer screening discussion: a randomized controlled trial. American Journal of Preventative Medicine. 2013 Apr;44(4):325-9.

15. Imperiale TF. After a negative screening colonoscopy, a microsimulation model shows that currently recommended strategies are equally effective for rescreening. Evidence Based Medicine. 2013 Oct;18(5):199-200.

16. Schwartz PH, Edenberg E, Barrett PR, Perkins SM, Meslin EM, Imperiale TF. Patient understanding of benefits, risks, and alternatives to screening colonoscopy. Family Medicine. 2013 Feb;45(2):83-9.

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