Thomas F. Imperiale, MD

Lawrence Lumeng Professor of Gastroenterology and Hepatology; Professor of Medicine, Indiana University School of Medicine
Research Scientist, Indiana University Center for Health Services and Outcomes Research
Research Scientist, William M. Tierney Center for Health Services Research, Regenstrief Institute, Inc.
Core Investigator, VA HSR&D Center for Health Information and Communication
Adjunct Professor, Richard M. Fairbanks School of Public Health at Indiana University-Purdue University of Indianapolis

     Dr. Imperiale is a Professor of Medicine in IU School of Medicine’s Division of Gastroenterology/Hepatology and staff gastroenterologist serving patients in four major Indiana hospitals. He holds research appointments in the IU Center for Health Services and Outcomes Research, the VA Center for Health Information and Communication, and Regenstrief Institute's William M. Tierney Center for Health Services Research.  His interests include tailoring screening for colorectal cancer based on individual patient risk, and using quantitative research methods in studying prevention of cirrhosis complications. Secondary research interests encompass prognosis and management of acute upper gastrointestinal hemorrhage, and assessment of new technologies to the application of digestive diseases.


   Recent recognition includes the Indiana University Trustee Teaching Award and Regenstrief Institute’s Outstanding Investigator Award.  Dr. Imperiale has mentored over thirty medical residents, faculty, and fellows. He is a named Fellow in the American Gastroenterological Association, a Member of the Association of American Physicians, and serves on the Editorial Boards of the journals, Annals of Internal Medicine and Evidence-Based Gastroenterology.  Dr. Imperiale’s publications include over 150 peer-reviewed articles.

Dr. Imperiale is board certified in Internal Medicine and a staff physician at the Richard L. Roudebush VA Medical Center in Indianapolis, Indiana.

Indiana University Health Profile



  Outcomes Research
  Colorectal Cancer Screening
  Upper Gastrointestinal Bleeding
  Technology Assessment for Digestive Diseases



Physician Group:  
     IU Health Physicians  
Hospital Privileges:  
     IU Health Methodist/IU Health University  
     Richard L. Roudebush VA Medical Center  



Residency      Case Western Reserve University
Internship      Case Western Reserve University
Fellowship      Yale University; Case Western Research University
School of Medicine      New York University

Active Projects

I. VA Cooperative Studies Program (2010-2015)

"Colonoscopy vs. Fecal Immunochemical Testing in Reducing Mortality from Colorectal Cancer (CONFIRM)" (PI) 

This study is to determine the true comparative effectiveness of colonoscopy relative to other proven non-invasive options.


II. Exact Sciences Corporation (2011-2015)

"Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advance Adenomatous Polyps and Cancer: DeeP-C Study." (PI)

Study is to determine the sensitivity and specificity of the Exact Colorectal Cancer (CRC) screening test for colorectal cancer, using colonoscopy as the reference method. The secondary objective is to compare the performance of the Exact CRC screening test to a commercially available FIT assay, both with respect to cancer and advanced adenoma.


III. Exact Sciences Corporation (2015-2019)

“”A Longitudinal Study of CologuardTM in an Average Risk Population Assessing a Three Year Test Interval” (PI)

The study objective is to collect longitudinal data on subjects prescribed Cologuard over the course of 3 years, to determine predictive value of the test, and to compare the observed versus expected reduction in colorectal cancer incidence.


Selected Publications                          |                          Go To PubMed List >>


1. Imler TD, Sherman S, Imperiale TF, Xu H, Ouyang F, Beesley C, Hilton C, Coté GA. Provider-specific quality measurement for ERCP using natural language processing. Gastrointest Endosc. 2017 May 3. pii: S0016-5107(17)31855-2. doi:10.1016/j.gie.2017.04.030. [Epub ahead of print] PubMed PMID: 28476375.

2. Imperiale TF, Ransohoff DF. Screening for Colorectal Neoplasia. N Engl J Med. 2017 Apr 20;376(16):1598-9. doi: 10.1056/NEJMc1702535. PubMed PMID: 28425279.

3. Bick BL, Imperiale TF, Johnson CS, DeWitt JM. Endoscopic suturing of esophageal fully covered self-expanding metal stents reduces rates of stent migration. Gastrointest Endosc. 2017 Apr 8. pii: S0016-5107(17)31783-2. doi:10.1016/j.gie.2017.03.1545. [Epub ahead of print] PubMed PMID: 28396273.

4. Militello LG, Diiulio JB, Borders MR, Sushereba CE, Saleem JJ, Haverkamp D, Imperiale TF. Evaluating a Modular Decision Support Application For Colorectal Cancer Screening. Appl Clin Inform. 2017 Feb 15;8(1):162-179. doi:10.4338/ACI-2016-09-RA-0152. PubMed PMID: 28197619; PubMed Central PMCID:PMC5373761.

5. Dalal KS, Coffing J, Imperiale TF. Adherence to Surveillance Guidelines in Nondysplastic Barrett's Esophagus. J Clin Gastroenterol. 2016 Dec 14. [Epub ahead of print] PubMed PMID: 27984402.

6. Imperiale TF, Yu M, Monahan PO, Stump TE, Tabbey R, Glowinski E, Ransohoff DF. Risk of Advanced Neoplasia Using the National Cancer Institute's Colorectal Cancer Risk Assessment Tool. J Natl Cancer Inst. 2016 Aug 31;109(1). pii: djw181.doi: 10.1093/jnci/djw181. Print 2017 Jan. PubMed PMID: 27582444.

7. ASGE Research Committee, Madhoun MF, Cote GA, Ahlawat SK, Ahmad NA, Buscaglia JM, Calderwood AH, Crockett S, Early DS, Gleeson FC, Gurudu SR, Imperiale TF, Liu JJ, Mosler P, Pannala R, Pfau PR, Romagnuolo J, Samadder J, Sethi A, Shergill AK, Shin EJ, Willingham F, Dominitz JA. Impact and outcomes of research sponsored by the American Society for Gastrointestinal Endoscopy. Gastrointest Endosc. 2016 Sep;84(3):385-391.e2. doi: 10.1016/j.gie.2016.04.013. Epub 2016 Jun 24. PubMedPMID: 27349928.

8. Imperiale TF, Rex DK. A new quality indicator of colonoscopy: caveat emptor. Gastrointest Endosc. 2016 Sep; 84(3):507-11. doi: 10.1016/j.gie.2016.05.004. Epub 2016 May 11. PubMed PMID: 27179689.

9. Rex DK, Imperiale TF. New Quality Measure Will Disincentivize Endoscopic Resection of Most Important Colorectal Lesions. Gastroenterology. 2016 May; 150(5):1249. doi: 10.1053/j.gastro.2015.12.044. Epub 2016 Mar 25. PubMed PMID: 27020339.

10. Bailey JR, Aggarwal A, Imperiale TF. Colorectal Cancer Screening: Stool DNA and Other Noninvasive Modalities. Gut Liver. 2016 Mar; 10(2):204-11. doi:10.5009/gnl15420. PubMed PMID: 26934885; PubMed Central PMCID:PMC4780449.

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